Synthesis and preclinical evaluation of [(11)C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

PURPOSE: Phosphodiesterase (PDE) 7 is a potential therapeutic target for neurological and inflammatory diseases, although in vivo visualization of PDE7 has not been successful. In this study, we aimed to develop [(11)C]MTP38 as a novel positron emission tomography (PET) ligand for PDE7. METHODS: [(1...

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Detalles Bibliográficos
Autores principales: Obokata, Naoyuki, Seki, Chie, Hirata, Takeshi, Maeda, Jun, Ishii, Hideki, Nagai, Yuji, Matsumura, Takehiko, Takakuwa, Misae, Fukuda, Hajime, Minamimoto, Takafumi, Kawamura, Kazunori, Zhang, Ming-Rong, Nakajima, Tatsuo, Saijo, Takeaki, Higuchi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426238/
https://www.ncbi.nlm.nih.gov/pubmed/33674894
http://dx.doi.org/10.1007/s00259-021-05269-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426238/
https://www.ncbi.nlm.nih.gov/pubmed/33674894
http://dx.doi.org/10.1007/s00259-021-05269-4

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