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Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity
Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar metabolites underlie the establishment of trained innate immun...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426275/ https://www.ncbi.nlm.nih.gov/pubmed/34522865 http://dx.doi.org/10.1016/j.isci.2021.103025 |
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author | Roberts, Lydia M. Schwarz, Benjamin Speranza, Emily Leighton, Ian Wehrly, Tara Best, Sonja Bosio, Catharine M. |
author_facet | Roberts, Lydia M. Schwarz, Benjamin Speranza, Emily Leighton, Ian Wehrly, Tara Best, Sonja Bosio, Catharine M. |
author_sort | Roberts, Lydia M. |
collection | PubMed |
description | Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar metabolites underlie the establishment of trained innate immunity. Therefore, host metabolism and this response are intimately linked. However, little is known regarding the influence of lipids on the development and function of trained immunity. Utilizing two models of pulmonary bacterial infection combined with multi-omic approaches, we identified persistent, pathogen-specific changes to the lung lipidome that correlated with differences in the trained immune response against a third unrelated pathogen. Further, we establish the specific cellular populations in the lung that contribute to this altered lipidome. Together these results expand our understanding of the pulmonary trained innate immune response and the contributions of host lipids in informing that response. |
format | Online Article Text |
id | pubmed-8426275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84262752021-09-13 Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity Roberts, Lydia M. Schwarz, Benjamin Speranza, Emily Leighton, Ian Wehrly, Tara Best, Sonja Bosio, Catharine M. iScience Article Resolution of infection results in development of trained innate immunity which is typically beneficial for defense against unrelated secondary infection. Epigenetic changes including modification of histones via binding of various polar metabolites underlie the establishment of trained innate immunity. Therefore, host metabolism and this response are intimately linked. However, little is known regarding the influence of lipids on the development and function of trained immunity. Utilizing two models of pulmonary bacterial infection combined with multi-omic approaches, we identified persistent, pathogen-specific changes to the lung lipidome that correlated with differences in the trained immune response against a third unrelated pathogen. Further, we establish the specific cellular populations in the lung that contribute to this altered lipidome. Together these results expand our understanding of the pulmonary trained innate immune response and the contributions of host lipids in informing that response. Elsevier 2021-08-24 /pmc/articles/PMC8426275/ /pubmed/34522865 http://dx.doi.org/10.1016/j.isci.2021.103025 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Roberts, Lydia M. Schwarz, Benjamin Speranza, Emily Leighton, Ian Wehrly, Tara Best, Sonja Bosio, Catharine M. Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
title | Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
title_full | Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
title_fullStr | Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
title_full_unstemmed | Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
title_short | Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
title_sort | pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426275/ https://www.ncbi.nlm.nih.gov/pubmed/34522865 http://dx.doi.org/10.1016/j.isci.2021.103025 |
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