The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice

As COVID-19 continues to spread rapidly worldwide and variants continue to emerge, the development and deployment of safe and effective vaccines are urgently needed. Here, we developed an mRNA vaccine based on the trimeric receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein fused to fe...

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Detalles Bibliográficos
Autores principales: Sun, Wenqiang, He, Lihong, Zhang, He, Tian, Xiaodong, Bai, Zhihua, Sun, Lei, Yang, Limin, Jia, Xiaojuan, Bi, Yuhai, Luo, Tingrong, Cheng, Gong, Fan, Wenhui, Liu, Wenjun, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426336/
https://www.ncbi.nlm.nih.gov/pubmed/34504054
http://dx.doi.org/10.1038/s41392-021-00750-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426336/
https://www.ncbi.nlm.nih.gov/pubmed/34504054
http://dx.doi.org/10.1038/s41392-021-00750-w

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