In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

In a biologic therapeutic landscape that requires versatility in targeting specificity, valency and half-life modulation, the monomeric Fc fusion platform holds exciting potential for the creation of a class of monovalent protein therapeutics that includes fusion proteins and bispecific targeting mo...

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Detalles Bibliográficos
Autores principales: Shan, Lu, Dyk, Nydia Van, Haskins, Nantaporn, Cook, Kimberly M., Rosenthal, Kim L., Mazor, Ronit, Dragulin-Otto, Sonia, Jiang, Yu, Wu, Herren, Dall’Acqua, William F., Borrok, Martin J., Damschroder, Melissa M., Oganesyan, Vaheh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426389/
https://www.ncbi.nlm.nih.gov/pubmed/34497355
http://dx.doi.org/10.1038/s42003-021-02565-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426389/
https://www.ncbi.nlm.nih.gov/pubmed/34497355
http://dx.doi.org/10.1038/s42003-021-02565-5

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