Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics

Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake of, or expel, various compounds from/into the venous blood stream. In the present...

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Detalles Bibliográficos
Autores principales: Ambrus, Csilla, Bakos, Éva, Sarkadi, Balázs, Özvegy-Laczka, Csilla, Telbisz, Ágnes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426393/
https://www.ncbi.nlm.nih.gov/pubmed/34497279
http://dx.doi.org/10.1038/s41598-021-97160-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426393/
https://www.ncbi.nlm.nih.gov/pubmed/34497279
http://dx.doi.org/10.1038/s41598-021-97160-3

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