Cargando…

Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis

A hallmark of chronic kidney disease is renal fibrosis, which can result in progressive loss of kidney function. Currently, there is no effective therapy for renal fibrosis. Therefore, there is an urgent need to identify potential drug targets for renal fibrosis. In this study, we examined the effec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiao, Baihai, An, Changlong, Tran, Melanie, Du, Hao, Wang, Penghua, Zhou, Dong, Wang, Yanlin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426438/ https://www.ncbi.nlm.nih.gov/pubmed/34512669 http://dx.doi.org/10.3389/fimmu.2021.735014

Ejemplares similares

STAT6 Deficiency Attenuates Myeloid Fibroblast Activation and Macrophage Polarization in Experimental Folic Acid Nephropathy
por: Jiao, Baihai, et al.
Publicado: (2021)

Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis
por: Wen, Jia, et al.
Publicado: (2022)

Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension
por: Wu, Yuanbo, et al.
Publicado: (2020)

Pharmacological Inhibition of STING/TBK1 Signaling Attenuates Myeloid Fibroblast Activation and Macrophage to Myofibroblast Transition in Renal Fibrosis
por: Zeng, Haimei, et al.
Publicado: (2022)

Pharmacologic inhibition of STAT5 in acute myeloid leukemia
por: Wingelhofer, Bettina, et al.
Publicado: (2018)

Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways
por: Park, Ji-Hyun, et al.
Publicado: (2018)

Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo
por: Chang, Yuqian, et al.
Publicado: (2023)

Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway
por: Li, Hongbo, et al.
Publicado: (2018)

Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals
por: Cai, Ze-hui, et al.
Publicado: (2022)

BMPER Ameliorates Renal Fibrosis by Inhibiting Tubular Dedifferentiation and Fibroblast Activation
por: Xie, Ting, et al.
Publicado: (2021)

Role of Bone Marrow-Derived Fibroblasts in Renal Fibrosis
por: Yan, Jingyin, et al.
Publicado: (2016)

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition
por: Giurisato, Emanuele, et al.
Publicado: (2018)

S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis
por: Zhang, Wei, et al.
Publicado: (2018)

Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206(+) M2-like macrophage polarization
por: Wang, Jie, et al.
Publicado: (2020)

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice
por: Li, Xi, et al.
Publicado: (2018)

Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway
por: Li, Zhen, et al.
Publicado: (2022)

SPI1/PU.1 controls fibroblast polarization and tissue fibrosis
por: Wohlfahrt, Thomas, et al.
Publicado: (2019)

CCR2 Regulates the Uptake of Bone Marrow-Derived Fibroblasts in Renal Fibrosis
por: Xia, Yunfeng, et al.
Publicado: (2013)

Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling
por: Zhang, Lei, et al.
Publicado: (2015)

Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway
por: Huang, Chongyang, et al.
Publicado: (2022)

Advances in the role of STAT3 in macrophage polarization
por: Xia, Tingting, et al.
Publicado: (2023)

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
por: Czimmerer, Zsolt, et al.
Publicado: (2018)

Inhibition of ROCK ameliorates pulmonary fibrosis by suppressing M2 macrophage polarisation through phosphorylation of STAT3
por: Li, Qingfang, et al.
Publicado: (2022)

N-acetyl cysteine ameliorates aortic fibrosis by promoting M2 macrophage polarization in aging mice
por: Zhu, Qing-yi, et al.
Publicado: (2021)

Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes
por: Zhang, Xiao-Wei, et al.
Publicado: (2016)

Targeting the RNA-Binding Protein QKI in Myeloid Cells Ameliorates Macrophage-Induced Renal Interstitial Fibrosis
por: de Bruin, Ruben G., et al.
Publicado: (2020)

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis
por: Yan, Yanli, et al.
Publicado: (2016)

Macrophage polarization in tissue fibrosis
por: Yang, Huidan, et al.
Publicado: (2023)

Smad3 Signaling Activates Bone Marrow-Derived Fibroblasts in Renal Fibrosis
por: Chen, Jiyuan, et al.
Publicado: (2014)

Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation
por: Guan, Ruijuan, et al.
Publicado: (2016)

MCC950 Ameliorates Acute Liver Injury Through Modulating Macrophage Polarization and Myeloid-Derived Suppressor Cells Function
por: Yan, Wei, et al.
Publicado: (2021)

Pharmacological inhibiting STAT5 for the treatment of FLT3‐ITD‐positive acute myeloid leukemia with triciribine phosphate monohydrate
por: Wu, Hong, et al.
Publicado: (2023)

Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice
por: Hsieh, Ching-Chuan, et al.
Publicado: (2018)

Margatoxin mitigates CCl4-induced hepatic fibrosis in mice via macrophage polarization, cytokine secretion and STAT signaling
por: Wu, Bao-Ming, et al.
Publicado: (2020)

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice
por: Zhang, Jian, et al.
Publicado: (2022)

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
por: Chakraborty, Debomita, et al.
Publicado: (2017)

C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice
por: Kimura, Toru, et al.
Publicado: (2016)

Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition
por: Zhang, Suping, et al.
Publicado: (2018)

Inhibition of CTGF ameliorates peritoneal fibrosis through suppression of fibroblast and myofibroblast accumulation and angiogenesis
por: Sakai, Norihiko, et al.
Publicado: (2017)

Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Through Fibroblast Dedifferentiation
por: Ugai, Keita, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v1mnagvofm4qsbshkqltsj6p87