Toward Development of Neuron Specific Transduction After Systemic Delivery of Viral Vectors

Widespread transduction of the CNS with a single, non-invasive systemic injection of adeno-associated virus is now possible due to the creation of blood-brain barrier-permeable capsids. However, as these capsids are mutants of AAV9, they do not have specific neuronal tropism. Therefore, it is necess...

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Detalles Bibliográficos
Autores principales: Finneran, Dylan J., Njoku, Ikenna P., Flores-Pazarin, Diego, Ranabothu, Meghana R., Nash, Kevin R., Morgan, David, Gordon, Marcia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426581/
https://www.ncbi.nlm.nih.gov/pubmed/34512509
http://dx.doi.org/10.3389/fneur.2021.685802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426581/
https://www.ncbi.nlm.nih.gov/pubmed/34512509
http://dx.doi.org/10.3389/fneur.2021.685802

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