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cGAS–STING and MyD88 Pathways Synergize in Ly6C(hi) Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production

The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway senses DNA and induces type I interferon (IFN) production. Whether and how the STING pathway crosstalk to other innate immune pathways during pathogen infection, however, remains unclear. Here, we showed that STING was n...

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Detalles Bibliográficos
Autores principales: Patel, Seema, Tucker, Heidi R., Gogoi, Himanshu, Mansouri, Samira, Jin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427188/
https://www.ncbi.nlm.nih.gov/pubmed/34512626
http://dx.doi.org/10.3389/fimmu.2021.699702