Cargando…
cGAS–STING and MyD88 Pathways Synergize in Ly6C(hi) Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production
The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway senses DNA and induces type I interferon (IFN) production. Whether and how the STING pathway crosstalk to other innate immune pathways during pathogen infection, however, remains unclear. Here, we showed that STING was n...
Autores principales: | Patel, Seema, Tucker, Heidi R., Gogoi, Himanshu, Mansouri, Samira, Jin, Lei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427188/ https://www.ncbi.nlm.nih.gov/pubmed/34512626 http://dx.doi.org/10.3389/fimmu.2021.699702 |
Ejemplares similares
-
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
por: Xia, Nengwen, et al.
Publicado: (2022) -
MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection
por: de Almeida, Leonardo A., et al.
Publicado: (2011) -
Activation of cGAS‐STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b(+)Ly6C(hi) Proinflammatory Monocytes
por: Du, Yang, et al.
Publicado: (2022) -
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
por: Domizio, Jeremy Di, et al.
Publicado: (2022) -
MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)