Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and –γ

PI3K-δ and PI3K-γ are critical regulators of T-cell differentiation, senescence, and metabolism. PI3K-δ and PI3K-γ signaling can contribute to T-cell inhibition via intrinsic mechanisms and regulation of suppressor cell populations, including regulatory T-cells and myeloid derived suppressor cells i...

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Detalles Bibliográficos
Autores principales: Chandrasekaran, Sanjay, Funk, Christopher Ronald, Kleber, Troy, Paulos, Chrystal M., Shanmugam, Mala, Waller, Edmund K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427697/
https://www.ncbi.nlm.nih.gov/pubmed/34512641
http://dx.doi.org/10.3389/fimmu.2021.718621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427697/
https://www.ncbi.nlm.nih.gov/pubmed/34512641
http://dx.doi.org/10.3389/fimmu.2021.718621

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