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cis-Diastereoselective Synthesis of Spirooxindolo-β-Lactams by Staudinger Cycloaddition with TsCl as Activating Co-reagent

[Image: see text] A convenient and versatile one-pot method for synthesis of 1,3-bis-aryl spirooxindolo-β-lactams from isatin Schiff bases and substituted phenylacetic acids using ketene–imine cycloaddition reaction with TsCl for a ketene generation has been developed. The reaction procedure does no...

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Detalles Bibliográficos
Autores principales: Filatov, Vadim E., Kuznetsova, Juliana, Petrovskaya, Lada, Yuzabchuk, Dmitry, Tafeenko, Victor A., Zyk, Nikolay V., Beloglazkina, Elena K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427784/
https://www.ncbi.nlm.nih.gov/pubmed/34514245
http://dx.doi.org/10.1021/acsomega.1c03063