Scaffold Hopping to Imidazo[1,2-a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

[Image: see text] Glutamate hyperfunction is implicated in multiple neurological and psychiatric diseases. Activation of the mGlu2 receptor results in reduced glutamate release and decreased excitability representing a promising novel therapeutic agent for the treatment of disorders such as epilepsy...

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Detalles Bibliográficos
Autores principales: de Lucas, Ana I., Vega, Juan A., García Molina, Aránzazu, Linares, María Lourdes, Tresadern, Gary, Lavreysen, Hilde, Oehlrich, Daniel, Trabanco, Andrés A., Cid, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427794/
https://www.ncbi.nlm.nih.gov/pubmed/34514269
http://dx.doi.org/10.1021/acsomega.1c03739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427794/
https://www.ncbi.nlm.nih.gov/pubmed/34514269
http://dx.doi.org/10.1021/acsomega.1c03739

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