Impaired B Cell Apoptosis Results in Autoimmunity That Is Alleviated by Ablation of Btk

While apoptosis plays a role in B-cell self-tolerance, its significance in preventing autoimmunity remains unclear. Here, we report that dysregulated B cell apoptosis leads to delayed onset autoimmune phenotype in mice. Our longitudinal studies revealed that mice with B cell-specific deletion of pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, Jacqueline A., Bazile, Cassandra, Clark, Emily S., Carlesso, Gianluca, Boucher, Justin, Kleiman, Eden, Mahmoud, Tamer, Cheng, Lily I., López-Rodríguez, Darlah M., Satterthwaite, Anne B., Altman, Norman H., Greidinger, Eric L., Khan, Wasif N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427801/
https://www.ncbi.nlm.nih.gov/pubmed/34512628
http://dx.doi.org/10.3389/fimmu.2021.705307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427801/
https://www.ncbi.nlm.nih.gov/pubmed/34512628
http://dx.doi.org/10.3389/fimmu.2021.705307

Ejemplares similares