Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo

PURPOSE: Oxidative stress-induced chondrocyte apoptosis and extracellular matrix (ECM) degradation plays an important role in the progression of osteoarthritis (OA). Bardoxolone methyl (BM), a semisynthetic triterpenoid, exerts strong effect against oxidative stress. The purpose of the present study...

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Detalles Bibliográficos
Autores principales: Pang, Zhiying, Jiang, Zengxin, Zhu, Runwen, Song, Chunfeng, Tang, Han, Cao, Lu, Guo, Changan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428116/
https://www.ncbi.nlm.nih.gov/pubmed/34511883
http://dx.doi.org/10.2147/DDDT.S314767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428116/
https://www.ncbi.nlm.nih.gov/pubmed/34511883
http://dx.doi.org/10.2147/DDDT.S314767

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