Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models

SIMPLE SUMMARY: Adoptively transferred T cells expressing recombinant chimeric antigen receptors (CAR T cells) have been approved for the therapy of hematological malignancies of the B cell lineage. However, CAR T cell therapy for patients with solid tumors so far has shown limited benefits. Correla...

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Detalles Bibliográficos
Autores principales: Csaplár, Marianna, Szöllősi, János, Gottschalk, Stephen, Vereb, György, Szöőr, Árpád
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428348/
https://www.ncbi.nlm.nih.gov/pubmed/34503109
http://dx.doi.org/10.3390/cancers13174301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428348/
https://www.ncbi.nlm.nih.gov/pubmed/34503109
http://dx.doi.org/10.3390/cancers13174301

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