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Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-γ(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation
Previously, we reported that herpes simplex virus type 1 (HSV-1) ICP22 binds to the CD80 promoter and suppresses its expression in vitro and in vivo. To better understand the impact of ICP22 binding to CD80 on HSV-1 infectivity and pathogenicity, we mapped the region of ICP22 required to bind the CD...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428405/ https://www.ncbi.nlm.nih.gov/pubmed/34287036 http://dx.doi.org/10.1128/JVI.01036-21 |