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Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-γ(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation

Previously, we reported that herpes simplex virus type 1 (HSV-1) ICP22 binds to the CD80 promoter and suppresses its expression in vitro and in vivo. To better understand the impact of ICP22 binding to CD80 on HSV-1 infectivity and pathogenicity, we mapped the region of ICP22 required to bind the CD...

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Detalles Bibliográficos
Autores principales:	Matundan, Harry H., Wang, Shaohui, Jaggi, Ujjaldeep, Yu, Jack, Ghiasi, Homayon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428405/ https://www.ncbi.nlm.nih.gov/pubmed/34287036 http://dx.doi.org/10.1128/JVI.01036-21

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