TCF-1 controls T(reg) functions that regulate inflammation, CD8 T-cell cytotoxicity, and severity of colon cancer.

The transcription factor TCF-1 is essential for the development and function of T regulatory (T(reg)) cells, however its function is poorly understood. Here, we show that TCF-1 primarily suppresses transcription of genes that are co-bound by Foxp3. Single-cell RNA-seq analysis identified effector- a...

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Detalles Bibliográficos
Autores principales: Osman, Abu, Yan, Bingyu, Li, Ying, Pavelko, Kevin D., Quandt, Jasmine, Saadalla, Abdulrahman, Singh, Mahendra Pal, Kazemian, Majid, Gounari, Fotini, Khazaie, Khashayarsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428683/
https://www.ncbi.nlm.nih.gov/pubmed/34385712
http://dx.doi.org/10.1038/s41590-021-00987-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428683/
https://www.ncbi.nlm.nih.gov/pubmed/34385712
http://dx.doi.org/10.1038/s41590-021-00987-1

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