Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells

Signaling via the B-cell receptor (BCR) is a key driver and therapeutic target in chronic lymphocytic leukemia (CLL). BCR stimulation of CLL cells induces expression of eIF4A, an initiation factor important for translation of multiple oncoproteins, and reduces expression of PDCD4, a natural inhibito...

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Detalles Bibliográficos
Autores principales: Wilmore, Sarah, Rogers-Broadway, Karly-Rai, Taylor, Joe, Lemm, Elizabeth, Fell, Rachel, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Coldwell, Mark, Packham, Graham, Yeomans, Alison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429177/
https://www.ncbi.nlm.nih.gov/pubmed/34398253
http://dx.doi.org/10.1007/s00018-021-03910-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429177/
https://www.ncbi.nlm.nih.gov/pubmed/34398253
http://dx.doi.org/10.1007/s00018-021-03910-x

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