DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

Molecular chaperones, including Hsp70/J-domain protein (JDP) families, play central roles in binding substrates to prevent their aggregation. How JDPs select different conformations of substrates remains poorly understood. Here, we report an interaction between the JDP DnaJC7 and tau that efficientl...

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Detalles Bibliográficos
Autores principales: Hou, Zhiqiang, Wydorski, Pawel M., Perez, Valerie A., Mendoza-Oliva, Aydé, Ryder, Bryan D., Mirbaha, Hilda, Kashmer, Omar, Joachimiak, Lukasz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429438/
https://www.ncbi.nlm.nih.gov/pubmed/34504072
http://dx.doi.org/10.1038/s41467-021-25635-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429438/
https://www.ncbi.nlm.nih.gov/pubmed/34504072
http://dx.doi.org/10.1038/s41467-021-25635-y

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