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Distinct calcium regulation of TRPM7 mechanosensitive channels at plasma membrane microdomains visualized by FRET-based single cell imaging

Transient receptor potential subfamily M member 7 (TRPM7), a mechanosensitive Ca(2+) channel, plays a crucial role in intracellular Ca(2+) homeostasis. However, it is currently unclear how cell mechanical cues control TRPM7 activity and its associated Ca(2+) influx at plasma membrane microdomains. U...

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Detalles Bibliográficos
Autores principales: Starostina, Irina, Jang, Yoon-Kwan, Kim, Heon-Su, Suh, Jung-Soo, Ahn, Sang-Hyun, Choi, Gyu-Ho, Suk, Myungeun, Kim, Tae-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429465/
https://www.ncbi.nlm.nih.gov/pubmed/34504177
http://dx.doi.org/10.1038/s41598-021-97326-z