Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Peptide backbone α-N-methylations change the physicochemical properties of amide bonds to provide structural constraints and other favorable characteristics including biological membrane permeability to peptides. Borosin natural product pathways are the only known ribosomally encoded and posttransla...

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Detalles Bibliográficos
Autores principales: Miller, Fredarla S., Crone, Kathryn K., Jensen, Matthew R., Shaw, Sudipta, Harcombe, William R., Elias, Mikael H., Freeman, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429565/
https://www.ncbi.nlm.nih.gov/pubmed/34504067
http://dx.doi.org/10.1038/s41467-021-25575-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429565/
https://www.ncbi.nlm.nih.gov/pubmed/34504067
http://dx.doi.org/10.1038/s41467-021-25575-7

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