Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity

The HRAS, NRAS, and KRAS genes are collectively mutated in a fifth of all human cancers. These mutations render RAS GTP-bound and active, constitutively binding effector proteins to promote signaling conducive to tumorigenic growth. To further elucidate how RAS oncoproteins signal, we mined RAS inte...

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Detalles Bibliográficos
Autores principales: Adhikari, Hema, Kattan, Walaa E., Kumar, Shivesh, Zhou, Pei, Hancock, John F., Counter, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429657/
https://www.ncbi.nlm.nih.gov/pubmed/34504076
http://dx.doi.org/10.1038/s41467-021-25523-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429657/
https://www.ncbi.nlm.nih.gov/pubmed/34504076
http://dx.doi.org/10.1038/s41467-021-25523-5

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