Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

The Spike (S) protein of SARS-CoV-2 binds ACE2 to direct fusion with host cells. S comprises a large external domain, a transmembrane domain, and a short cytoplasmic tail. Understanding the intracellular trafficking of S is relevant to SARS-CoV-2 infection, and to vaccines expressing full-length S f...

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Detalles Bibliográficos
Autores principales: Cattin-Ortolá, Jérôme, Welch, Lawrence G., Maslen, Sarah L., Papa, Guido, James, Leo C., Munro, Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429659/
https://www.ncbi.nlm.nih.gov/pubmed/34504087
http://dx.doi.org/10.1038/s41467-021-25589-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429659/
https://www.ncbi.nlm.nih.gov/pubmed/34504087
http://dx.doi.org/10.1038/s41467-021-25589-1

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