Themis regulates metabolic signaling and effector functions in CD4(+) T cells by controlling NFAT nuclear translocation

Themis is a T cell lineage-specific molecule that is involved in TCR signal transduction. The effects of germline Themis deletion on peripheral CD4(+) T cell function have not been described before. In this study, we found that Themis-deficient CD4(+) T cells had poor proliferative responses, reduce...

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Detalles Bibliográficos
Autores principales: Prasad, Mukul, Brzostek, Joanna, Gautam, Namrata, Balyan, Renu, Rybakin, Vasily, Gascoigne, Nicholas R. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429700/
https://www.ncbi.nlm.nih.gov/pubmed/33177694
http://dx.doi.org/10.1038/s41423-020-00578-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429700/
https://www.ncbi.nlm.nih.gov/pubmed/33177694
http://dx.doi.org/10.1038/s41423-020-00578-4

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