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Themis regulates metabolic signaling and effector functions in CD4(+) T cells by controlling NFAT nuclear translocation
Themis is a T cell lineage-specific molecule that is involved in TCR signal transduction. The effects of germline Themis deletion on peripheral CD4(+) T cell function have not been described before. In this study, we found that Themis-deficient CD4(+) T cells had poor proliferative responses, reduce...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429700/ https://www.ncbi.nlm.nih.gov/pubmed/33177694 http://dx.doi.org/10.1038/s41423-020-00578-4 |