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RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines
Ras-specific proteases to degrade RAS within cancer cells are under active development as an innovative strategy to treat tumorigenesis. The naturally occurring biological toxin effector called RAS/RAP1-specific endopeptidase (RRSP) is known to cleave all RAS within a cell, including HRAS, KRAS, NRA...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429734/ https://www.ncbi.nlm.nih.gov/pubmed/34504197 http://dx.doi.org/10.1038/s41598-021-97422-0 |