Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the first exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding and consequential aggregation of CAG-expanded mutant HTT (mHTT) underpin HD pathology. Our interest in the life cycle of...

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Detalles Bibliográficos
Autores principales: Herrmann, Frank, Hessmann, Manuela, Schaertl, Sabine, Berg-Rosseburg, Karola, Brown, Christopher J, Bursow, Galina, Chiki, Anass, Ebneth, Andreas, Gehrmann, Miriam, Hoeschen, Nicole, Hotze, Madlen, Jahn, Stefanie, Johnson, Peter D, Khetarpal, Vinod, Kiselyov, Alex, Kottig, Karsten, Ladewig, Stefanie, Lashuel, Hilal, Letschert, Sven, Mills, Matthew R, Petersen, Kathrin, Prime, Michael E, Scheich, Christoph, Schmiedel, Gerhard, Wityak, John, Liu, Longbin, Dominguez, Celia, Muñoz-Sanjuán, Ignacio, Bard, Jonathan A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429736/
https://www.ncbi.nlm.nih.gov/pubmed/34504195
http://dx.doi.org/10.1038/s41598-021-97334-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429736/
https://www.ncbi.nlm.nih.gov/pubmed/34504195
http://dx.doi.org/10.1038/s41598-021-97334-z

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