Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains

Ionotropic glutamate receptors (iGluRs) mediate signal transmission in the brain and are important drug targets. Structural studies show snapshots of iGluRs, which provide a mechanistic understanding of gating, yet the rapid motions driving the receptor machinery are largely elusive. Here we detect...

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Detalles Bibliográficos
Autores principales: Rajab, Suhaila, Bismin, Leah, Schwarze, Simone, Pinggera, Alexandra, Greger, Ingo H., Neuweiler, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429746/
https://www.ncbi.nlm.nih.gov/pubmed/34504293
http://dx.doi.org/10.1038/s42003-021-02605-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429746/
https://www.ncbi.nlm.nih.gov/pubmed/34504293
http://dx.doi.org/10.1038/s42003-021-02605-0

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