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Allosteric coupling of sub-millisecond clamshell motions in ionotropic glutamate receptor ligand-binding domains
Ionotropic glutamate receptors (iGluRs) mediate signal transmission in the brain and are important drug targets. Structural studies show snapshots of iGluRs, which provide a mechanistic understanding of gating, yet the rapid motions driving the receptor machinery are largely elusive. Here we detect...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429746/ https://www.ncbi.nlm.nih.gov/pubmed/34504293 http://dx.doi.org/10.1038/s42003-021-02605-0 |