Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

A predominant trigger and driver of sporadic Alzheimer’s disease (AD) is the synergy of brain oxidative stress and glucose hypometabolism starting at early preclinical stages. Oxidative stress damages macromolecules, while glucose hypometabolism impairs cellular energy supply and antioxidant defense...

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Detalles Bibliográficos
Autores principales: Malkov, Anton, Popova, Irina, Ivanov, Anton, Jang, Sung-Soo, Yoon, Seo Yeon, Osypov, Alexander, Huang, Yadong, Zilberter, Yuri, Zilberter, Misha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429759/
https://www.ncbi.nlm.nih.gov/pubmed/34504272
http://dx.doi.org/10.1038/s42003-021-02551-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429759/
https://www.ncbi.nlm.nih.gov/pubmed/34504272
http://dx.doi.org/10.1038/s42003-021-02551-x

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