Immune Checkpoint Inhibitors Regulate K(+) Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients

Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca(2+) fluxes, and thereby T cell effector functions. In HNSCC patients, PD-1 blockade increases K...

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Detalles Bibliográficos
Autores principales: Gawali, Vaibhavkumar S., Chimote, Ameet A., Newton, Hannah S., Feria-Garzón, Manuel G., Chirra, Martina, Janssen, Edith M., Wise-Draper, Trisha M., Conforti, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429813/
https://www.ncbi.nlm.nih.gov/pubmed/34512366
http://dx.doi.org/10.3389/fphar.2021.742862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429813/
https://www.ncbi.nlm.nih.gov/pubmed/34512366
http://dx.doi.org/10.3389/fphar.2021.742862

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