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Immune Checkpoint Inhibitors Regulate K(+) Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients

Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca(2+) fluxes, and thereby T cell effector functions. In HNSCC patients, PD-1 blockade increases K...

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Detalles Bibliográficos
Autores principales:	Gawali, Vaibhavkumar S., Chimote, Ameet A., Newton, Hannah S., Feria-Garzón, Manuel G., Chirra, Martina, Janssen, Edith M., Wise-Draper, Trisha M., Conforti, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429813/ https://www.ncbi.nlm.nih.gov/pubmed/34512366 http://dx.doi.org/10.3389/fphar.2021.742862

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