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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Regulate Macrophage Polarization to Attenuate Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage in Mice

BACKGROUND AND OBJECTIVES: To investigate the effect and the underlying mechanism of exosomes secreted by human umbilical cord mesenchymal stem cells (hUCMSCs) on diffuse alveolar hemorrhage (DAH) in murine lupus. METHODS AND RESULTS: Exosomes were extracted from cultured hUCMSCs by ultracentrifugat...

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Detalles Bibliográficos
Autores principales: Chen, Xun, Wei, Qing, Sun, Hongmei, Zhang, Xiaobo, Yang, Changrong, Tao, Ying, Nong, Guangmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429939/
https://www.ncbi.nlm.nih.gov/pubmed/33906978
http://dx.doi.org/10.15283/ijsc20156