Cargando…
Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair
Phosphorylation (activation) and dephosphorylation (deactivation) of the slit diaphragm proteins NEPHRIN and NEPH1 are critical for maintaining the kidney epithelial podocyte actin cytoskeleton and, therefore, proper glomerular filtration. However, the mechanisms underlying these events remain large...
Autores principales: | Solanki, Ashish K., Arif, Ehtesham, Srivastava, Pankaj, Furcht, Christopher M., Rahman, Bushra, Wen, Pei, Singh, Avinash, Holzman, Lawrence B., Fitzgibbon, Wayne R., Budisavljevic, Milos N., Lobo, Glenn P., Kwon, Sang-Ho, Han, Zhe, Lazzara, Matthew J., Lipschutz, Joshua H., Nihalani, Deepak |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8429977/ https://www.ncbi.nlm.nih.gov/pubmed/34391780 http://dx.doi.org/10.1016/j.jbc.2021.101079 |
Ejemplares similares
-
Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function
por: Sagar, Amin, et al.
Publicado: (2017) -
Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond
por: Martin, Claire E., et al.
Publicado: (2018) -
MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes
por: Ni, Jie, et al.
Publicado: (2016) -
The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes
por: Solanki, Ashish K., et al.
Publicado: (2019) -
Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes
por: Tanigawa, Shunsuke, et al.
Publicado: (2018)