Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis

The prognosis of oral squamous cell carcinoma (OSCC) largely depends on the control of lymph node metastases. We evaluate the therapeutic efficacy of G47Δ, a third-generation oncolytic herpes simplex virus type 1 (HSV-1), in mouse tongue cancer models. Intratumoral injection with G47Δ prolonged the...

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Detalles Bibliográficos
Autores principales: Uchihashi, Toshihiro, Nakahara, Hirokazu, Fukuhara, Hiroshi, Iwai, Miwako, Ito, Hirotaka, Sugauchi, Akinari, Tanaka, Minoru, Kogo, Mikihiko, Todo, Tomoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430046/
https://www.ncbi.nlm.nih.gov/pubmed/34553027
http://dx.doi.org/10.1016/j.omto.2021.06.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430046/
https://www.ncbi.nlm.nih.gov/pubmed/34553027
http://dx.doi.org/10.1016/j.omto.2021.06.008

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