Deep Sequencing of MHC-Adapted Viral Lines Reveals Complex Recombinational Exchanges With Endogenous Retroviruses Leading to High-Frequency Variants

Experimental evolution (serial passage) of Friend virus complex (FVC) in mice demonstrates phenotypic adaptation to specific host major histocompatibility complex (MHC) genotypes. These evolved viral lines show increased fitness and virulence in their host-genotype-of-passage, but display fitness an...

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Detalles Bibliográficos
Autores principales: Middlebrook, Earl A., Stark, Derek L., Cornwall, Douglas H., Kubinak, Jason L., Potts, Wayne K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430262/
https://www.ncbi.nlm.nih.gov/pubmed/34512727
http://dx.doi.org/10.3389/fgene.2021.716623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430262/
https://www.ncbi.nlm.nih.gov/pubmed/34512727
http://dx.doi.org/10.3389/fgene.2021.716623

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