Cargando…

Optimizing oxytocin LC-MS/MS sensitivity by choosing the right column

OBJECTIVE: Sensitivity is often an issue in bioanalytical LC-MS/MS applications. Commonly investigated parameters to improve it include additives to mobile phase, derivatization and sample-preparation. The nature of the column, however, is not frequently evaluated. DESIGN AND METHODS: The sensitivit...

Descripción completa

Detalles Bibliográficos
Autor principal:	Ackermans, Mariëtte T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430380/ https://www.ncbi.nlm.nih.gov/pubmed/34527802 http://dx.doi.org/10.1016/j.plabm.2021.e00254

Ejemplares similares

Explaining unexplained hypoglycemia: How LC-MS/MS can help
por: Ackermans, M.T., et al.
Publicado: (2022)

Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS
por: Yu, Shuo, et al.
Publicado: (2017)

Analysis of Serotonin in Human Feces Using Solid Phase Extraction and Column-Switching LC-MS/MS
por: Hirabayashi, Yukiko, et al.
Publicado: (2020)

Optimal precursor ion selection for LC-MALDI MS/MS
por: Zerck, Alexandra, et al.
Publicado: (2013)

Optimization of the CYP inhibition assay using LC-MS/MS
por: Abduraman, Muhammad Asyraf, et al.
Publicado: (2022)

Determination of Phthalate Metabolites in Human Serum and Urine as Biomarkers for Phthalate Exposure Using Column-Switching LC-MS/MS
por: Jeong, Jee Yeon, et al.
Publicado: (2011)

GOAT – A simple LC-MS/MS gradient optimization tool
por: Trudgian, David C, et al.
Publicado: (2014)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Development and Validation of a Simple LC-MS Method for the Quantification of Oxytocin in Dog Saliva
por: Wang, Lei, et al.
Publicado: (2019)

A Sensitive LC-MS/MS Method for Palytoxin Using Lithium Cationization
por: Klijnstra, Mirjam D., et al.
Publicado: (2018)

Enhanced LC-ESI-MS/MS Sensitivity by Cationic Derivatization of Organophosphorus Acids
por: Shamai Yamin, Tamar, et al.
Publicado: (2023)

Optimization of Carob Products Preparation for Targeted LC-MS/MS Metabolomics Analysis
por: Deda, Olga, et al.
Publicado: (2023)

LC-MS/MS for Ultra-Sensitive Quantification of Multiple Estrogens in the Blood and Brain
por: Jalabert, Cecilia, et al.
Publicado: (2021)

Deep and Highly Sensitive Proteome Coverage by LC-MS/MS Without Prefractionation
por: Thakur, Suman S., et al.
Publicado: (2011)

The Optimized Workflow for Sample Preparation in LC-MS/MS-Based Urine Proteomics
por: Saito, Suguru, et al.
Publicado: (2019)

Fecal metabolite analysis of Japanese macaques in Yakushima by LC-MS/MS and LC-QTOF-MS
por: TSUCHIDA, Sayaka, et al.
Publicado: (2021)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Rapid, Sensitive and Reliable Ricin Identification in Serum Samples Using LC–MS/MS
por: Feldberg, Liron, et al.
Publicado: (2021)

Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A
por: Zhang, Kai
Publicado: (2021)

Application of LC–MS/MS in the Mycotoxins Studies
por: Gámiz-Gracia, Laura, et al.
Publicado: (2020)

Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis
por: D’Hondt, Matthias, et al.
Publicado: (2014)

LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
por: Rakibe, Uday, et al.
Publicado: (2018)

Quantification of 3,4-Dimethyl-1H-Pyrazole Using Ion-Pair LC–MS/MS on a Reversed-Phase Column
por: Doran, Gregory S, et al.
Publicado: (2022)

Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach
por: Araujo-León, Jesús Alfredo, et al.
Publicado: (2020)

MUSCLE: automated multi-objective evolutionary optimization of targeted LC-MS/MS analysis
por: Bradbury, James, et al.
Publicado: (2015)

Optimization of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics
por: Anderson, James R., et al.
Publicado: (2020)

Potential of poly(styrene-co-divinylbenzene) monolithic columns for the LC-MS analysis of protein digests
por: van de Meent, Michiel H. M., et al.
Publicado: (2010)

Validation of LC-MS/MS Coupled with a Chiral Column for the Determination of 3- or 15-Acetyl Deoxynivalenol Mycotoxins from Fusarium graminearum in Wheat
por: Wang, Lan, et al.
Publicado: (2021)

Determination of 355 Pesticides in Lemon and Lemon Juice by LC-MS/MS and GC-MS/MS
por: Aslantas, Sule, et al.
Publicado: (2023)

Absorption and Metabolism Characteristics of Triptolide as Determined by a Sensitive and Reliable LC-MS/MS Method
por: Gong, Xiaomei, et al.
Publicado: (2015)

A Selective and Sensitive LC-MS/MS Method for Quantitation of Indole in Mouse Serum and Tissues
por: Joshi, Vineet, et al.
Publicado: (2022)

Fast and sensitive LC–MS/MS method for the simultaneous determination of lisinopril and hydrochlorothiazide in human plasma
por: Shah, Jaivik V., et al.
Publicado: (2017)

Pigments’ analysis of Citrus juicing making by‐products by LC‐MS/MS and LC‐DAD
por: Myrtsi, Eleni D., et al.
Publicado: (2022)

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS
por: Lam, Anh K., et al.
Publicado: (2022)

Evaluation of LC-MS and LC×LC-MS in analysis of zebrafish embryo samples for comprehensive lipid profiling
por: Xu, Mengmeng, et al.
Publicado: (2020)

Integrated LC-MS/MS system for plant metabolomics
por: Sawada, Yuji, et al.
Publicado: (2013)

Determination of Nine Fentanyl Drugs in Hair Samples by GC-MS/MS and LC-MS/MS
por: Wei, Qi, et al.
Publicado: (2022)

Optimization of a Simplified and Effective Analytical Method of Pesticide Residues in Mealworms (Tenebrio molitor Larvae) Combined with GC–MS/MS and LC–MS/MS
por: Kim, Leesun, et al.
Publicado: (2020)

Lipid Discovery by Combinatorial Screening and Untargeted LC-MS/MS
por: Bilgin, Mesut, et al.
Publicado: (2016)

Development and validation of Lenalidomide in human plasma by LC-MS/MS
por: Ranganathan, Premanand, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_147a2410f6ecdj75djinh4292e