Cargando…
Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry
Melanoma is the most aggressive type of skin cancer due to its high capability of developing metastasis and acquiring chemoresistance. Altered redox homeostasis induced by increased reactive oxygen species is associated with melanomagenesis through modulation of redox signaling pathways. Dysfunction...
Autores principales: | de Melo, Fabiana Henriques Machado, Gonçalves, Diego Assis, de Sousa, Ricardo Xisto, Icimoto, Marcelo Yudi, Fernandes, Denise de Castro, Laurindo, Francisco R. M., Jasiulionis, Miriam Galvonas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430733/ https://www.ncbi.nlm.nih.gov/pubmed/34502464 http://dx.doi.org/10.3390/ijms22179556 |
Ejemplares similares
-
The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin
por: Gonçalves, Diego Assis, et al.
Publicado: (2021) -
Disruption of Redox Homeostasis by Alterations in Nitric Oxide Synthase Activity and Tetrahydrobiopterin along with Melanoma Progression
por: Soares, Jaqueline Pereira Moura, et al.
Publicado: (2022) -
Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation
por: Molognoni, Fernanda, et al.
Publicado: (2013) -
Correction: Ras and Rac1, Frequently Mutated in Melanomas, Are Activated by Superoxide Anion, Modulate Dnmt1 Level and Are Causally Related to Melanocyte Malignant Transformation
por: Molognoni, Fernanda, et al.
Publicado: (2015) -
Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase
por: Tobias, Silke, et al.
Publicado: (2015)