Cargando…

Overview of Ferroptosis and Synthetic Lethality Strategies

Ferroptosis, a term first proposed in 2012, is iron-dependent, non-apoptotic regulatory cell death induced by erastin. Ferroptosis was originally discovered during synthetic lethal screening for drugs sensitive to RAS mutant cells, and is closely related to synthetic lethality. Ferroptosis sensitize...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kinowaki, Yuko, Taguchi, Towako, Onishi, Iichiroh, Kirimura, Susumu, Kitagawa, Masanobu, Yamamoto, Kouhei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430824/ https://www.ncbi.nlm.nih.gov/pubmed/34502181 http://dx.doi.org/10.3390/ijms22179271

Ejemplares similares

To Discover the Efficient and Novel Drug Targets in Human Cancers Using CRISPR/Cas Screening and Databases
por: Onishi, Iichiroh, et al.
Publicado: (2021)

Bone marrow niches in myeloid neoplasms
por: Kitagawa, Masanobu, et al.
Publicado: (2019)

Subcellular localization of MCM2 correlates with the prognosis of ovarian clear cell carcinoma
por: Aihemaiti, Gulinisha, et al.
Publicado: (2018)

Identification of NRAS Downstream Genes with CRISPR Activation Screening
por: Tatsumi, Akiya, et al.
Publicado: (2022)

Quantitative high-throughput analysis of tumor infiltrating lymphocytes in breast cancer
por: Hayashi, Kumiko, et al.
Publicado: (2022)

CRISPR screening identifies M1AP as a new MYC regulator with a promoter-reporter system
por: Yamamoto, Akiko, et al.
Publicado: (2020)

Regulation of 4-HNE via SMARCA4 Is Associated with Worse Clinical Outcomes in Hepatocellular Carcinoma
por: Watabe, Shiori, et al.
Publicado: (2023)

Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone
por: Koyanagi, Anri, et al.
Publicado: (2022)

Efficient Identification of the MYC Regulator with the Use of the CRISPR Library and Context-Matched Database Screenings
por: Tanaka, Yosuke, et al.
Publicado: (2022)

Spatial and Quantitative Analysis of Tumor-Associated Macrophages: Intratumoral CD163-/PD-L1+ TAMs as a Marker of Favorable Clinical Outcomes in Triple-Negative Breast Cancer
por: Shinohara, Hajime, et al.
Publicado: (2022)

Epigenetic based synthetic lethal strategies in human cancers
por: Gao, Aiai, et al.
Publicado: (2020)

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis
por: Verma, Nandini, et al.
Publicado: (2020)

Current management strategies for visceral artery aneurysms: an overview
por: Obara, Hideaki, et al.
Publicado: (2019)

Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
por: Li, Kailin, et al.
Publicado: (2021)

Synthetic Lethality in Ovarian Cancer
por: Chandrasekaran, Akshaya, et al.
Publicado: (2021)

DNA repair and synthetic lethality
por: Guo, Gong-she, et al.
Publicado: (2011)

Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics
por: Shimomura, Iwao, et al.
Publicado: (2019)

Current concept of stress fractures with an additional category of atypical fractures: a perspective review with representative images
por: Oh, Yoto, et al.
Publicado: (2021)

Ferroptosis in Liver Diseases: An Overview
por: Capelletti, Martina Maria, et al.
Publicado: (2020)

Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction
por: Kerins, Michael J., et al.
Publicado: (2018)

Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers
por: Yao, Kun, et al.
Publicado: (2021)

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell–cell interactions
por: Sugita, Keisuke, et al.
Publicado: (2023)

Overview of lethal human coronaviruses
por: Chen, Bin, et al.
Publicado: (2020)

Synthetic Lethality Targeting Polθ
por: Drzewiecka, Małgorzata, et al.
Publicado: (2022)

Synthetic lethality strategies: Beyond BRCA1/2 mutations in pancreatic cancer
por: Hu, Yunlong, et al.
Publicado: (2020)

An Overview of the Ferroptosis Hallmarks in Friedreich’s Ataxia
por: Turchi, Riccardo, et al.
Publicado: (2020)

A Primary Kidney Giant Cell Tumor of Soft Tissue Caused Peritoneal Dissemination, Considered to Be Malignant Transformation: A Case Report
por: Hata, Chiina, et al.
Publicado: (2023)

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies
por: Lu, Qili, et al.
Publicado: (2019)

Breast Cancer Predisposition Genes and Synthetic Lethality
por: Neiger, Hannah E., et al.
Publicado: (2021)

Approaches to Identifying Synthetic Lethal Interactions in Cancer
por: Thompson, Jordan M., et al.
Publicado: (2015)

Synthetic lethality: emerging targets and opportunities in melanoma
por: Thompson, Nicola, et al.
Publicado: (2017)

Epigenetic synthetic lethality approaches in cancer therapy
por: Yang, Haoshen, et al.
Publicado: (2019)

Harnessing Synthetic Lethal Interactions for Personalized Medicine
por: Shieh, Grace S.
Publicado: (2022)

Modeling synthetic lethality
por: Le Meur, Nolwenn, et al.
Publicado: (2008)

Targeting MCM2 function as a novel strategy for the treatment of highly malignant breast tumors
por: Abe, Shinya, et al.
Publicado: (2015)

Correction to: Current management strategies for visceral artery aneurysms: an overview
por: Obara, Hideaki, et al.
Publicado: (2020)

CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer
por: Castells-Roca, Laia, et al.
Publicado: (2021)

Synthetic lethality in lung cancer and translation to clinical therapies
por: Leung, Ada W. Y., et al.
Publicado: (2016)

Computational methods, databases and tools for synthetic lethality prediction
por: Wang, Jing, et al.
Publicado: (2022)

Metabolic Perturbation and Synthetic Biology Strategies for Plant Terpenoid Production—An Updated Overview
por: Mani, Vimalraj, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nopau84fbjt72is49juuoqnp6p