Inhibition of the Eukaryotic 80S Ribosome as a Potential Anticancer Therapy: A Structural Perspective

SIMPLE SUMMARY: Unravelling the molecular basis of ribosomal inhibition by small molecules is crucial to characterise the function of potential anticancer drugs. After approval of the ribosome inhibitor homoharringtonine for treatment of CML, it became clear that acting on the rate of protein synthe...

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Detalles Bibliográficos
Autores principales: Pellegrino, Simone, Terrosu, Salvatore, Yusupova, Gulnara, Yusupov, Marat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430933/
https://www.ncbi.nlm.nih.gov/pubmed/34503202
http://dx.doi.org/10.3390/cancers13174392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8430933/
https://www.ncbi.nlm.nih.gov/pubmed/34503202
http://dx.doi.org/10.3390/cancers13174392

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