A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML

HOXA9 and MEIS1 are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression data of pre-leukemic (overexpressing Hoxa9) and leukemogenic (...

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Detalles Bibliográficos
Autores principales: Hassan, Jacob Jalil, Lieske, Anna, Dörpmund, Nicole, Klatt, Denise, Hoffmann, Dirk, Kleppa, Marc-Jens, Kustikova, Olga S., Stahlhut, Maike, Schwarzer, Adrian, Schambach, Axel, Maetzig, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431012/
https://www.ncbi.nlm.nih.gov/pubmed/34502319
http://dx.doi.org/10.3390/ijms22179411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431012/
https://www.ncbi.nlm.nih.gov/pubmed/34502319
http://dx.doi.org/10.3390/ijms22179411

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