Cargando…

A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML

HOXA9 and MEIS1 are frequently upregulated in acute myeloid leukemia (AML), including those with MLL-rearrangement. Because of their pivotal role in hemostasis, HOXA9 and MEIS1 appear non-druggable. We, thus, interrogated gene expression data of pre-leukemic (overexpressing Hoxa9) and leukemogenic (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hassan, Jacob Jalil, Lieske, Anna, Dörpmund, Nicole, Klatt, Denise, Hoffmann, Dirk, Kleppa, Marc-Jens, Kustikova, Olga S., Stahlhut, Maike, Schwarzer, Adrian, Schambach, Axel, Maetzig, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431012/ https://www.ncbi.nlm.nih.gov/pubmed/34502319 http://dx.doi.org/10.3390/ijms22179411

Ejemplares similares

A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML
por: Lieske, Anna, et al.
Publicado: (2022)

Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory
por: Stahlhut, Maike, et al.
Publicado: (2021)

Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic Barcoding
por: Maetzig, Tobias, et al.
Publicado: (2022)

Competitive sgRNA Screen Identifies p38 MAPK as a Druggable Target to Improve HSPC Engraftment
por: Klatt, Denise, et al.
Publicado: (2020)

HOXA9/MEIS1 targets in leukemia: reinforced signaling networks and therapeutic opportunities
por: Zhou, Xinyue, et al.
Publicado: (2022)

The Deficiency of Tumor Suppressor Prep1 Accelerates the Onset of Meis1- Hoxa9 Leukemogenesis
por: Dardaei, Leila, et al.
Publicado: (2014)

Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State
por: Amin, Shilu, et al.
Publicado: (2015)

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice
por: Muranyi, Andrew, et al.
Publicado: (2022)

Expression of meis and hoxa11 in dipnoan and teleost fins provides new insights into the evolution of vertebrate appendages
por: Langellotto, Fernanda, et al.
Publicado: (2018)

Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia
por: Wiktorin, Hanna Grauers, et al.
Publicado: (2016)

Meis2 as a critical player in MN1-induced leukemia
por: Lai, C K, et al.
Publicado: (2017)

MOZ is critical for the development of MOZ/MLL fusion–induced leukemia through regulation of Hoxa9/Meis1 expression
por: Katsumoto, Takuo, et al.
Publicado: (2022)

Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance
por: Wang, Wei, et al.
Publicado: (2022)

HOXA11 plays critical roles in disease progression and response to cytarabine in AML
por: Fu, Jen-Fen, et al.
Publicado: (2021)

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia
por: Mohr, Sebastian, et al.
Publicado: (2017)

The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice
por: Lavau, Catherine P., et al.
Publicado: (2020)

The methyltransferase G9a regulates HoxA9-dependent transcription in AML
por: Lehnertz, Bernhard, et al.
Publicado: (2014)

An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis
por: Jung, Namyoung, et al.
Publicado: (2015)

Mei : per flauto solo (1962)
por: Fukushima, Kazuo
Publicado: (1966)

miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
por: Li, Zejuan, et al.
Publicado: (2012)

Defining the transcriptional control of pediatric AML highlights RARA as a superenhancer-regulated druggable dependency
por: Perez, Monika W., et al.
Publicado: (2021)

Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells
por: Ghasemi, Reza, et al.
Publicado: (2020)

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells
por: Dassé, E, et al.
Publicado: (2012)

Tumor-Suppressive Role of microRNA-202-3p in Hepatocellular Carcinoma Through the KDM3A/HOXA1/MEIS3 Pathway
por: Zhang, Yijie, et al.
Publicado: (2021)

Structural insights reveal the specific recognition of meiRNA by the Mei2 protein
por: Shen, Siyuan, et al.
Publicado: (2022)

Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
por: Li, Zejuan, et al.
Publicado: (2018)

My mentors (Dascălii mei)
por: Bârsu, Cristian
Publicado: (2013)

Meis: New friends of Pax
por: Schulte, Dorothea
Publicado: (2014)

MEIS1 in Hematopoiesis and Cancer. How MEIS1-PBX Interaction Can Be Used in Therapy
por: Blasi, Francesco, et al.
Publicado: (2021)

Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML
por: Yao, Jie, et al.
Publicado: (2014)

Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells
por: Baron, Yvonne, et al.
Publicado: (2022)

Regulation of the MEI-1/MEI-2 Microtubule-Severing Katanin Complex in Early Caenorhabditis elegans Development
por: Beard, Sarah M., et al.
Publicado: (2016)

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia
por: Ropa, James, et al.
Publicado: (2018)

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas
por: Jäger, Daniela, et al.
Publicado: (2017)

Gammaretroviral Vectors: Biology, Technology and Application
por: Maetzig, Tobias, et al.
Publicado: (2011)

First person – Mei-Fang Lin
Publicado: (2019)

The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth
por: Anderson, Garrett H, et al.
Publicado: (2005)

Genetic and phenotypic continuum of HOXA genes: A case with double HOXA9/HOXA13 mutations
por: Jaouadi, Hager, et al.
Publicado: (2023)

Expression of Concern: Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML
Publicado: (2021)

Study of the dynamic expression of Meis1 in mice
por: Hai-Xia, Li, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_uhu7c596lbsves1f56mktqdo4e