In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone as Promising Cyclooxygenase Inhibitors

Since long-term use of classic NSAIDs can cause severe side effects related mainly to the gastroduodenal tract, discovery of novel cyclooxygenase inhibitors with a safe gastric profile still remains a crucial challenge. Based on the most recent literature data and previous own studies, we decided to...

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Detalles Bibliográficos
Autores principales: Peregrym, Krzysztof, Szczukowski, Łukasz, Wiatrak, Benita, Potyrak, Katarzyna, Czyżnikowska, Żaneta, Świątek, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431030/
https://www.ncbi.nlm.nih.gov/pubmed/34502040
http://dx.doi.org/10.3390/ijms22179130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431030/
https://www.ncbi.nlm.nih.gov/pubmed/34502040
http://dx.doi.org/10.3390/ijms22179130

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