Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts

Alpha-synucleinopathies are featured by fibrillar inclusions in brain cells. Although α-synuclein fibrils display structural diversity, the origin of this diversity is not fully understood. We used molecular dynamics simulations to design synthetic peptides, based on the NAC 71-82 amino acid fragmen...

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Detalles Bibliográficos
Autores principales: Näsström, Thomas, Dahlberg, Tobias, Malyshev, Dmitry, Ådén, Jörgen, Andersson, Per Ola, Andersson, Magnus, Karlsson, Björn C. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431055/
https://www.ncbi.nlm.nih.gov/pubmed/34502242
http://dx.doi.org/10.3390/ijms22179334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431055/
https://www.ncbi.nlm.nih.gov/pubmed/34502242
http://dx.doi.org/10.3390/ijms22179334

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