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Myeloma–Bone Interaction: A Vicious Cycle via TAK1–PIM2 Signaling
SIMPLE SUMMARY: Myeloma cells interact with their ambient cells in the bone, such as bone marrow stromal cells, osteoclasts, and osteocytes, resulting in enhancement of osteoclastogenesis and inhibition of osteoblastogenesis while enhancing their growth and drug resistance. The activation of the TAK...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431187/ https://www.ncbi.nlm.nih.gov/pubmed/34503251 http://dx.doi.org/10.3390/cancers13174441 |