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Myeloma–Bone Interaction: A Vicious Cycle via TAK1–PIM2 Signaling

SIMPLE SUMMARY: Myeloma cells interact with their ambient cells in the bone, such as bone marrow stromal cells, osteoclasts, and osteocytes, resulting in enhancement of osteoclastogenesis and inhibition of osteoblastogenesis while enhancing their growth and drug resistance. The activation of the TAK...

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Detalles Bibliográficos
Autores principales:	Harada, Takeshi, Hiasa, Masahiro, Teramachi, Jumpei, Abe, Masahiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431187/ https://www.ncbi.nlm.nih.gov/pubmed/34503251 http://dx.doi.org/10.3390/cancers13174441

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