Cargando…

The Antihypertensive Drug Telmisartan Protects Oligodendrocytes from Cholesterol Accumulation and Promotes Differentiation by a PPAR-γ-Mediated Mechanism

Our previous studies have demonstrated that specific peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists play a fundamental role in oligodendrocyte progenitor (OP) differentiation, protecting them against oxidative and inflammatory damage. The antihypertensive drug Telmisartan (TLM) was s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bernardo, Antonietta, Malara, Mariagiovanna, Bertuccini, Lucia, De Nuccio, Chiara, Visentin, Sergio, Minghetti, Luisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431237/ https://www.ncbi.nlm.nih.gov/pubmed/34502342 http://dx.doi.org/10.3390/ijms22179434

Ejemplares similares

Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ
por: Bernardo, Antonietta, et al.
Publicado: (2021)

NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation
por: De Nuccio, Chiara, et al.
Publicado: (2020)

Regulation of Glial Cell Functions by PPAR-γ Natural and Synthetic Agonists
por: Bernardo, Antonietta, et al.
Publicado: (2008)

Adenosine A(2A) receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes
por: De Nuccio, Chiara, et al.
Publicado: (2019)

PPAR-γ, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches
por: Malchiodi-Albedi, Fiorella, et al.
Publicado: (2008)

Myelin Defects in Niemann–Pick Type C Disease: Mechanisms and Possible Therapeutic Perspectives
por: Bernardo, Antonietta, et al.
Publicado: (2021)

Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity
por: Ayza, Muluken Altaye, et al.
Publicado: (2020)

hMTH1 expression protects mitochondria from Huntington's disease-like impairment
por: Ventura, Ilenia, et al.
Publicado: (2013)

Telmisartan Potentiates Insulin Secretion via Ion Channels, Independent of the AT1 Receptor and PPARγ
por: Liu, Tao, et al.
Publicado: (2021)

Antihypertensive treatment with telmisartan in a cat with amlodipine-induced gingival hyperplasia
por: Desmet, Lien, et al.
Publicado: (2017)

Attenuation of Immune-Mediated Renal Injury by Telmisartan, an Angiotensin Receptor Blocker and a Selective PPAR-γ Activator
por: Hamano, Yuki, et al.
Publicado: (2011)

Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan
por: Li, Pengshou, et al.
Publicado: (2020)

Corrigendum to ‘Antihypertensive treatment with telmisartan in a cat with amlodipine-induced gingival hyperplasia’
Publicado: (2022)

Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass
por: Kolli, Vipula, et al.
Publicado: (2014)

PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2017)

PPARγ Agonists Promote Oligodendrocyte Differentiation of Neural Stem Cells by Modulating Stemness and Differentiation Genes
por: Kanakasabai, Saravanan, et al.
Publicado: (2012)

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury
por: Zhang, Qingxiu, et al.
Publicado: (2019)

Connectivity mapping of angiotensin-PPAR interactions involved in the amelioration of non-alcoholic steatohepatitis by Telmisartan
por: Park, Jung Gyu, et al.
Publicado: (2019)

Correction: PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2019)

Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels
por: Liu, Jinfeng, et al.
Publicado: (2015)

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma
por: Ning, Zhen, et al.
Publicado: (2022)

Influence of G-protein β-Polypeptide 3 C825T Polymorphism on Antihypertensive Response to Telmisartan and Amlodipine in Chinese Patients
por: Zhang, Zan-Lin, et al.
Publicado: (2016)

Telmisartan and cardioprotection
por: Akhrass, Philippe R, et al.
Publicado: (2011)

Repurposing Dipyridamole in Niemann Pick Type C Disease: A Proof of Concept Study
por: Pepponi, Rita, et al.
Publicado: (2022)

Telmisartan Activates PPARδ to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice
por: Li, Yingxiao, et al.
Publicado: (2017)

Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions
por: Ajmone-Cat, Maria Antonietta, et al.
Publicado: (2010)

PPARγ in Neuroblastoma
por: Peri, Alessandro, et al.
Publicado: (2008)

Corrigendum: Bilirubin Increases Insulin Sensitivity by Regulating Cholesterol Metabolism, Adipokines and PPARγ Levels
por: Liu, Jinfeng, et al.
Publicado: (2016)

PPARγ is a major driver of the accumulation and phenotype of adipose-tissue T(reg) cells
por: Cipolletta, Daniela, et al.
Publicado: (2012)

Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases
por: Kulkarni, Ajit A., et al.
Publicado: (2012)

Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma
por: Salim, Mohamed M., et al.
Publicado: (2023)

Efficacy and safety of low‐dose antihypertensive combination of amlodipine, telmisartan, and chlorthalidone: A randomized, double‐blind, parallel, phase II trial
por: Sung, Ki‐Chul, et al.
Publicado: (2022)

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2
por: Wang, Siying, et al.
Publicado: (2023)

PPARγ and Apoptosis in Cancer
por: Elrod, Heath A., et al.
Publicado: (2008)

PPARγ, neuroinflammation, and disease
por: Mrak, Robert E, et al.
Publicado: (2004)

Nutraceuticals as Ligands of PPARγ
por: Penumetcha, Meera, et al.
Publicado: (2012)

PPARγ and Cognitive Performance
por: d’Angelo, Michele, et al.
Publicado: (2019)

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex
por: Lemkul, Justin A., et al.
Publicado: (2015)

PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression
por: Ye, Guozhu, et al.
Publicado: (2019)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_29ct3021dif75p4vmkp5a0p9f8