Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-β1 Signaling

This study probed the largely unexplored regulation and role of fibronectin in Angiotensin II-stimulated cardiac fibroblasts. Using gene knockdown and overexpression approaches, Western blotting, and promoter pull-down assay, we show that collagen type I-activated Discoidin Domain Receptor 2 (DDR2)...

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Detalles Bibliográficos
Autores principales: Titus, Allen Sam, Venugopal, Harikrishnan, Ushakumary, Mereena George, Wang, Mingyi, Cowling, Randy T., Lakatta, Edward G., Kailasam, Shivakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431251/
https://www.ncbi.nlm.nih.gov/pubmed/34502259
http://dx.doi.org/10.3390/ijms22179343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431251/
https://www.ncbi.nlm.nih.gov/pubmed/34502259
http://dx.doi.org/10.3390/ijms22179343

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