MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA

Folate depletion causes chromosomal instability by increasing DNA strand breakage, uracil misincorporation, and defective repair. Folate mediated one-carbon metabolism has been suggested to play a key role in the carcinogenesis and progression of hepatocellular carcinoma (HCC) through influencing DN...

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Detalles Bibliográficos
Autores principales: Wu, Ming-Tsung, Ye, Wei-Ting, Wang, Yi-Cheng, Chen, Po-Ming, Liu, Jun-You, Tai, Chien-Kuo, Tang, Feng-Yao, Li, Jian-Rong, Liu, Chun-Chi, Chiang, En-Pei Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431311/
https://www.ncbi.nlm.nih.gov/pubmed/34502300
http://dx.doi.org/10.3390/ijms22179392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8431311/
https://www.ncbi.nlm.nih.gov/pubmed/34502300
http://dx.doi.org/10.3390/ijms22179392

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